Why isn’t ChemDraw keeping my custom settings for the toolbars?
The settings for the toolbars are stored in the Windows registry. If you are not logged in as an administrator those changes will not be saved.
In order to make sure your changes get saved, please right-click on the ChemDraw icon and select “Run as Administrator”. The changes will be saved automatically when you quit the program.
Note: Our developers are aware of this behavior and we hope to allow making these changes without the need of admin rights in a future release of the software.