I'd like for ChemDraw for Excel to use different drawing/text settings for structures.
After you create a ChemDraw worksheet and add some structures, you can change the style used for those structures. In Excel, select the structures that you would like to change. Go to the ChemOffice menu in Excel and choose the Molecule submenu and then choose Style. If you have a ChemDraw Style Sheet that contains the desired settings, point to it here. We store a number of different style sheets in the ChemDraw Itms folder.
If you would like to change the default settings such that any time you create a new ChemDraw worksheet in Excel it uses some default settings for structures, browse to the ChemDraw Items folder and open the "New document.cds" file in ChemDraw. Change the document settings and then save your changes. Excel uses this file's settings when adding new structures to the worksheet.