I am not able to open any ChemDraw files. I get an error message stating that the file could not be found. I am also unable to open any of the templates associated with ChemDraw, but I can see the templates listed.
Make sure a printer driver is chosen, even if you are not connected to a printer. Go to the Chooser, which is found in the Apple menu, and click on a printer driver (i.e. LaserWriter), then close the Chooser and retest.