Whenever I try to draw or drag something in ChemDraw, it tries to access the A:\ or floppy drive.
ChemDraw is probably looking for your CD_Items directory on the floppy drive. Have your serial number and registration code handy. Open your Windows directory, and delete the chemdraw.ini file. Launch ChemDraw, and reenter your registration information. This will reset your preferences such that ChemDraw will look in the correct location for the CD_Items directory.