When I print from ChemDraw, the entire graphic is about 1/4 of the normal size and is located in the upper left corner of the printed page.
This bug has been fixed in the latest version of ChemDraw.
In ChemDraw 3.5, this bug only occurs under the following environment:
printing resolution set to 600 dpi
HP PCL driver being used
To work around the bug, alter one of the variables. The easiest solution is to change the resolution of the printout to 300 dpi. The resolution can be changed in the Print Setup window.