The error suggests that there is an issue with permissions on the 'PerkinElmerInformatics' folder located at following location of Windows 10 machine:
Please follow the steps below to provide the full control permission to this folder.
- Right click on PerkinElmerInformatics folder.
- Go to Properties - Security.
- Click on Edit and check 'Full Control'.
- Click on Apply - Ok.
- Try activating ChemDraw now.